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Big surprise, the relationship between endocannabinoids and phytocannabinoids is way more complex than many suspected. When a person smokes marijuana, THC overwhelms the EC system, quickly attaching to cannabinoid receptors throughout the brain and body. This interferes with the ability of natural cannabinoids to do their job of fine-tuning communication between neurons, which can throw the entire system off balance. For example, CBN is known for its ability to help reduce the side effects of those who suffer from sleep disorders. CBC is popular for its ability to regulate pain and reduce inflammation.
This may explain why many users prefer topical CBD use for pain relief. Outside of the endocannabinoid system, CBD interacts with the same neuron receptors that many drugs interact with, such as opioid receptors for pain regulation and dopamine receptors which regulate behavior and cognition. Further research has uncovered much more about how human cannabinoid receptors and receptors in cannabis compounds, such as THC and CBD, interact.
In the Sanofi-Aventis study, researchers administered “Rimonabant,” a CB1 antagonist, to obese individuals. Users lost weight and girth across the board, and only about 10% of users reported negative effects such as depression, anxiety, and nausea. Additionally, globally elevating 2-AG by decreasing MAGL response can overload the endocannabinoid system resulting in a protective shutdown or down regulation of many CB1 receptors in the brain. The most consistent results so far have shown that peripheral pain signals can be lowered by raising anandamide and 2-AG levels just near the site of origin of the pain.
The study targeted the body’s feeding control center located in the hypothalamus region of the brain. This region has a high concentration of CB1 receptors, which, when stimulated with THC, is responsible for the “munchies.” This receptor also controls the normal desire to eat. In theory, preventing the activation of this receptor should suppress the urge to eat. CB1 receptors are also found outside the brain, where they regulate the energy metabolism in the liver and fat tissue. In animal studies, blocking CB1 resulted in less body weight, even when the same amount of food was consumed.
Phytocannabinoids, on the other hand, are produced by cannabis plants. The endocannabinoid system is comprised of a series of receptors, enzymes and endogenous cannabinoids. Tetrahydrocannabinol is another prominent cannabinoid found in cannabis. It’s the compound that gets you “high.” Once in our body, THC interacts with our ECS by binding to receptors, just like endocannabinoids.
What Is Cbd Distillate: Everything You Need To Know
In addition to acting as an anti-inflammatory and aiding sleep, CBG promotes healthy bone growth. Because of their individual effects, many hemp farmers have learned how to grow strains of plants that produce even more of the desired cannabinoid. Endogenous cannabinoids include anandamide and 2-AG and are produced by our bodies to interact with CB1 and CB2 receptors.
And, as we already mentioned, CB receptors have a cbdoilcreamsus.com huge impact on the health of your cells. So sampling products that can stimulate their activity could be beneficial to your entire body. As we already mentioned, cannabinoids like THC and CBD bind to the cannabinoid receptors located throughout your body.
One way to boost your ECS is to use high-quality hemp extract products. In fact, a full-spectrum CBD product also contains a wide range of phytocannabinoids, each of which will interact differently with CB receptors throughout your body.
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- You can also utilize CBD hemp oil, which is cannabidiol extracted from hemp plants that don’t contain the psychoactive chemical THC.
- The simplest way is to put a few drops under your tongue for absorption.
- You can also mix CBD oil with a carrier oil and rub it into your skin, bake it into your favorite snacks, or even put it in an e-cigarette.
- If you’re looking for an experimental alternative for traditional anxiolytic drugs like Xanax and Prozac, think about trying to balance your endocannabinoid system.
- When you’re feeling run-down or tired, you consider taking vitamin supplements.
For instance, while THC may bind directly with a CB receptor, CBD may choose not to bind directly, instead of modifying its ability to bind with other cannabinoids. CBD, therefore, has a greater impact on the function of CB receptors and the overall endocannabinoid system. CBD and the other main endocannabinoid – 2-arachidonoylglycerol (2-AG) – are active at both cannabinoid receptors. 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management. Instead of binding to cannabinoid receptors, CBD binds to our serotonin receptors, and this is just one of many receptors with which CBD is interacting.